Published in the Journal of Agricultural and Food Chemistry, a joint study between the Roswell Park Cancer Institute, New Zealand Institute for Crop and Food Research Limited and the Johns Hopkins University, found that bladder tissue is particularly responsive to Sulforaphane. Rats were fed a broccoli sprout extract via oral intubation or included in their dietary feed.  Subsequent urinary output showed dose dependent high levels of isothiocyanate metabolites with no sign of toxicity.  These findings suggest that Sulforaphane may be especially effective in protecting against bladder cancer. (Zhang, Y, et al., November 2006).

There is evidence that glucosinolates metabolized (producing dithiocarbamates in the urine) within a matter of hours in both animal and human clinical studies. I'll cite the Kensler Qidong study, Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2605-13.

Hi there and Welcome!  Please feel free to post questions and comments about BroccoSprouts, SGS, research, etc.

I just spotted a new article this morning about a research study being conducted at University of Virginia, delving deeper into the workings of sulforaphane. http://sf1.novisgroup.com/n.php?n=71363&m=1niuo17&c=nshjgnwwqvuvsvk

This project "will build on research . . . that reported that nutrients in broccoli unexpectedly bond with a specific enzyme in cells (MIS), previously linked to inflammatory disease processes. . . . mice that did not have the gene for this enzyme developed far fewer cancers when given carcinogens."

Quite some time ago, I received a phone call from a diabetic who told me that after eating BroccoSprouts no sugar appeared in her urine. At the time, no one, to my knowledge, was studying the effects of sulforaphane on diabetes. However, I never forgot that phone call and have often wondered if thiswas/is the subject of exploration.  I logged onto PubMed.gov and came up with this abstract. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16504726&query_hl=4&itool=pubmed_docsum
In this study in Poland, the scientists found that "sulforaphane improved islet function in vivo, indicating that the combination of a free radical scavenger and an antioxidant (sulforaphane) may be used to increase the effectiveness of islet transplantation."

Any thoughts or comments?

I know that the scientists are continuing the studies on SGS and skin cancer, and I think a skin cream is in development, but I don't know the status on that.

Friday August 25, 2006, Tony Talalay, CEO of Brassica Protection Products, LLC (BPP) and Dr. Jed Fahey will be interviewed about BroccoSprouts on ABC News Now, the 24-hour news network.  BroccoSprouts will be featured in a segment entitled "The Food Doctor" on the show Money Matters.  Howard Moskowitz, the famous Food Doctor, will conduct an eight-minute interview with Jed and Tony.  The segment, which highlights the most innovative and interesting aspects of the food industry, airs at 9:30am on Friday and also streams to AOL, Comcast, Yahoo, and ABC news pages. Here's a link to the video. http://abcnews.go.com/Video/playerIndex?id=2356707

This is all work in progress.  There are some people who are missing certain forms (isozymes or isoforms) of certain phase 2 enzymes.  Even the idea of whether these people would benefit more or less from enhanced Phase 2 enzyme activity is not totally clear and is the subject of ongoing research. The tests exist, but are not at this point suitable for such a consumer-type screening program.

I am aware of  no scientific evidence to support this.  Clearly, too much of any good thing could be harmful --- sunlight, water, and salt come to mind as extreme examples.

Christian,

Sorry for the delay.  Yes there are a large number of Phase II enzymes that can all be induced by SGS and these same enzymes can be induced by the same mechanism (Nrf2), by things like tea, curcumin, etc.

Hundreds of Phase II enzymes exist in the body and scientists haven't yet identified all of them.  As far as they know, most of the enzymes are induced by the same inducers, but there are tissue differences in the delivery of sulforaphane to different tissues.  However, there should be no difference in the response to SGS whether it comes from tea or sprouts.

A few Phase II enzymes induced by sulforaphane include glutathione S-transferase (GST), UDP Glucuronosyl Transferase, Sulfotransferase and NAD(P)H: quinone oxido reductase (NQO).

Other Phase II enzyme inducers include Quercetin, ECGC (tea), Pinostrobin and Myricetin (Honey).

I just finished reading a paper - and will read it several more times just to understand it - illustrating the complexity of the chemopreventive properties of phytochemicals.  It's called Cancer Chemoprevention with Dietary Phytochemicals by Young-Joon Surh. Nature Reviews - Cancer, October 2003, Vol. 3. I'll be happy to send you a copy if you like. You can PM me.

6 ounces.

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