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Title: SGS Phase II Inducer? Post by: Christianzetterberg on July 21, 2006, 11:36:51 PM Hi Lance I hope your still there. It seems I'm having trouble posting. I have a simple question I was hoping you could answer. Since there are a number of Phase II enzymes, which of these are induced by SGS, and can other Phase II enzymes be induced by tea, curcumin and etc.., or are they the same enzymes.
CZ Title: Phase II inducer? Post by: kas on July 27, 2006, 12:57:32 PM Christian,
Sorry for the delay. Yes there are a large number of Phase II enzymes that can all be induced by SGS and these same enzymes can be induced by the same mechanism (Nrf2), by things like tea, curcumin, etc. Hundreds of Phase II enzymes exist in the body and scientists haven't yet identified all of them. As far as they know, most of the enzymes are induced by the same inducers, but there are tissue differences in the delivery of sulforaphane to different tissues. However, there should be no difference in the response to SGS whether it comes from tea or sprouts. A few Phase II enzymes induced by sulforaphane include glutathione S-transferase (GST), UDP Glucuronosyl Transferase, Sulfotransferase and NAD(P)H: quinone oxido reductase (NQO). Other Phase II enzyme inducers include Quercetin, ECGC (tea), Pinostrobin and Myricetin (Honey). I just finished reading a paper - and will read it several more times just to understand it - illustrating the complexity of the chemopreventive properties of phytochemicals. It's called Cancer Chemoprevention with Dietary Phytochemicals by Young-Joon Surh. Nature Reviews - Cancer, October 2003, Vol. 3. I'll be happy to send you a copy if you like. You can PM me. |