http://www.livestrong.com/article/94227-broccoli-sprouts-nutrition/
Livestrong.com gives a nice overview of the power of BroccoSprouts. Take a look!
Filed under: SGS on March 17th, 2010 | No Comments »
According to researchers at Harbin Medical University in China, their study, published in Oncology Reports February 2010, strongly supports the contention that P38 mitogen-activated protein kinase (known as p38 MAPK) is a pivotal and efficient target of sulforaphane in the chemoprevention of bladder cancer.
Citation:
Oncol Rep. 2010 Apr;23(4):1133-8.
p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells. Shan Y, Wang X, Wang W, He C, Bao Y.
Abstract:
Sulforaphane, a well-characterised dietary isothiocyanate, has been demonstrated to be a potent anti-carcinogenic agent in numerous cancer models, including in bladder cancer cells. In the present study, sulforaphane up-regulated the expression of two Nrf2-dependent enzymes, glutathione transferase (GSTA1-1) and thioredoxin reductase (TR-1), and down-regulated cyclooxygenase 2 (COX-2) in human bladder cancer T24 cells. This action of sulforaphane was associated with the p38 MAPK activity. When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression. Moreover, it was established that anisomycin increased nuclear translocation of Nrf2, whereas SB202190 abrogated sulforaphane-induced Nrf2 translocation into the nucleus. In summary, these data suggest that p38 MAPK activation can regulate Nrf2-antioxidant response element (ARE)-driven enzymes and COX-2 expression, thereby facilitating the role of sulforaphane in cancer prevention. This study strongly supports the contention that p38 MAPK is a pivotal and efficient target of sulforaphane in the chemoprevention of bladder cancer.
Filed under: SGS on March 8th, 2010 | No Comments »
Researchers at Wayne State University reported that sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells. 
To put it in simpler terms, in this laboratory study, sulforaphane was shown to stop the growth and promote the programmed cell death (apatosis) of Epithelial Ovarian Cancer cells. These researchers concluded that sulforaphane and a chemotherapeutic drug (they tested paclitaxel) in combination could produce more promising results (more cancer cell death) than the standard chemotherapy of ovarian cancer which usually consists of paclitaxel alone or in combination with platinum based drugs.
http://www.molecular-cancer.com/content/9/1/47
CONCLUSIONS section from the study:
“Sulforaphane induces growth arrest and apoptosis (cell death) in Epithelial Ovarian Cancer cells by inhibiting RB phosphorylation and reduction in the levels of free E2F-1. In summary, we have provided evidence that Sulforaphane suppresses growth of Epithelial Ovarian Cancer cells in vitro by contributing to the modulation of cell cycle regulatory proteins and by increasing the apoptosis. These effects may be correlated to the observed inhibition of cell migration. These observations highlight the possibility that Sulforaphane may be a good candidate for combination therapy of Epithelial Ovarian Cancer with paclitaxel.”
Mol Cancer. 2010 Mar 2;9(1):47. Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells. Bryant CS, Kumar S, Chamala S, Shah J, Pal J, Haider M, Seward S, Qazi AM, Morris R, Semaan A, Shammas MA, Steffes C, Potti RB, Prasad M, Weaver DW, Batchu RB.
Filed under: SGS on March 4th, 2010 | No Comments »
This is a summary from the Tufts University Health & Nutrition Letter, Feb 2010 (accessible at www.tuftshealthletter.com via subscription):
What’s so special about green tea?
Jeffrey B. Blumberg, PhD, director of Tufts’ HNRCA Antioxidants Research Laboratory reports in the Feb 2010 Tufts University Health & Nutrition Letter, “As investigators continue to study the multiple effects that tea has on human health, more research supports tea’s potential in helping reduce the incidence of major
diseases,” he says. “In some respects, it is good to think of tea as a plant food, much like fruits and vegetables.”
Blumberg continues to say that “Observational studies in Asia show benefits of green tea and observational studies in the US, UK and the Netherlands show benefits of black tea.” But, herbal tea is not included in such research showing benefits against chronic disease, according to Blumberg.
The newsletter continues: “Yale University scientists have suggested that green tea might be the explanation for the so-called ‘Asian paradox’: Why don’t people in Asian countries, where smoking remains more popular than in the US, consistently suffer heart disease and lung cancer at the same rate as Americans? The flavonoids in green tea, researchers suggest, may be partly responsible by maintaining artery function, inhibiting clots and blocking tumor growth.
“Taken altogether, the evidence certainly suggests that incorporating at least a few cups of green tea every day will positively affect your health,” says Diane L. McKay, PhD, another scientist at Tufts’ Antioxidants Research Laboratory who’s studied tea. “It’s not going to cure anything and shouldn’t be consumed as a drug, but it can complement an overall healthy diet.”
Filed under: SGS on March 3rd, 2010 | No Comments »
Data from the UK’s University of Reading suggests that sulforaphane may protect against nerve cell injury which is relevant to the cause of Parkinson’s disease. This study was just published Feb 17, 2010 in the Molecular Nutrition & Food Research journal.
See abstract below.
1. Mol Nutr Food Res. 2010 Feb 17. [Epub ahead of print]
Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes.
Vauzour D, Buonfiglio M, Corona G, Chirafisi J, Vafeiadou K, Angeloni C, Hrelia S, Hrelia P, Spencer JP.
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, Whiteknights, Reading, UK.
The degeneration of dopaminergic neurons in the substantia nigra has been linked to the formation of the endogenous neurotoxin 5-S-cysteinyl-dopamine. Sulforaphane (SFN), an isothiocyanate derived from the corresponding precursor glucosinolate found in cruciferous vegetables has been observed to exert a range
of biological activities in various cell populations. In this study, we show that SFN protects primary cortical neurons against 5-S-cysteinyl-dopamine induced neuronal injury. Pre-treatment of cortical neurons with SFN (0.01-1 muM) resulted in protection against 5-S-cysteinyl-dopamine-induced neurotoxicity, which peaked at 100 nM. This protection was observed to be mediated by the ability of SFN to modulate the extracellular signal-regulated kinase 1 and 2 and the activation of Kelch-like ECH-associated protein 1/NF-E2-related factor-2 leading to the increased expression and activity of glutathione-S-transferase (M1, M3 and M5), glutathione reductase, thioredoxin reductase and NAD(P)H oxidoreductase . These data suggest that SFN stimulates the NF-E2-related factor-2 pathway of antioxidant gene expression in neurons and may protect against neuronal injury relevant to the aetiology of Parkinson’s disease.
PMID: 20166144 [PubMed - as supplied by publisher]
Filed under: SGS, brain on February 25th, 2010 | No Comments »
A study from the Catholic University of Korea in Seoul suggests 
that the sulforaphane may offer a new therapeutic approach for the treatment of chronic autoimmune arthritis.
The antiarthritic and immune regulatory effects of SFN, which were confirmed in vivo, suggest that sulforaphane may offer a possible treatment option for rheumatoid arthritis (RA).
Citation:
Kong JS, Yoo SA, Kim HS, Kim HA, Yea K, Ryu SH, Chung YJ, Cho CS, Kim WU. Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate. Arthritis Rheum. 2010 Jan;62(1):159-70.
Filed under: SGS, rheumatoid arthritis (RA), sprouts on February 17th, 2010 | No Comments »
According to the World Health Organization (WHO), more than 12 million people are diagnosed with cancer each year; however, approximately two out of five cancers are potentially preventable.
This year, the WHO is acknowledging World Cancer Day (February 4) by promoting ways to ease the global burden of cancer. This year’s theme is “Cancer Can Be Prevented Too,” which focuses on simple ways to prevent cancer, such as stop smoking, limit alcohol consumption, avoid too much sun, and maintain a healthy weight through diet and exercise.
Source: www.CBSNews.com.
Filed under: books and articles, cancer on February 5th, 2010 | No Comments »
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Filed under: antioxidants on February 3rd, 2010 | No Comments »
So, all of the other New Year’s Resolutions may have gone by the wayside, but simply adding an ounce (1/2 cup) of BroccoSprouts broccoli sprouts to your breakfast (or lunch or dinner) is an easy, positive change you can make.
And remember, not all broccoli sprouts are alike. Dr. Paul Talalay and his colleagues at Johns Hopkins University School of Medicine have tested more than 50 varieties of broccoli seeds. Their work shows that some types of broccoli seeds provide much more sulforaphane GS than others. Only BroccoSprouts are grown from these special seeds, which are tested by Brassica Protection Products and grown under conditions to ensure they contain certified levels of sulforaphane GS.
Filed under: SGS on February 2nd, 2010 | No Comments »
There will be no delay of game with this easy substitution for your Super Bowl party!!
Why not make an easy improvement to standard Super Bowl fare with some healthy, flavorful players instead of the same old ingredients?
In our healthier, tastier version, simply replace the shredded lettuce on your taco with BroccoSprouts® Broccoli Sprouts. Get your antioxidants and amazing taste!
Check back for more great Super Bowl Substitutions!
Filed under: SGS on January 31st, 2010 | No Comments »
