Q & A with Dr. Jed Fahey

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Q:  How does SGS reduce the risk of cancer?
 
A:  A complex process, detoxification involves the coordinate stimulation of enzyme inducers with different functions.  Some detoxify free radicals --highly reactive molecules linked to the development of cancer. Other enzymes reduce free radical creation, and some conjugate carcinogens, allowing for more effective and rapid elimination from the body.  In other words, a carcinogen that would normally accumulate in the fat tissues of the body can be conjugated to a molecule whose production is triggered by a chemoprotective enzyme, and become more water-soluble and thus more readily excreted in the urine.


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Biography Dr. Jed Fahey Print E-mail

Dr. Jed W. Fahey M.S., Sc.D.

Director of the Brassica Chemoprotection Laboratory
Faculty Research Associate, Dept. of Pharmacology, Johns Hopkins University School of Medicine

                                                                                          Dr. Jed Fahey

Dr. Jed W. Fahey M.S., Sc.D. is a Faculty Research Associate in the Department of   Pharmacology, Laboratory of Molecular Pharmacology at the Johns Hopkins University School of Medicine. He is also a plant physiologist who manages Johns Hopkins University's Brassica Chemoprotection Laboratory, where he has been involved in developing cruciferous plants as chemoprotective agents.                                                                               

In recent years, Dr. Fahey's work at the Brassica Chemoprotection Laboratory led to the discovery that broccoli sprouts are an exceptionally rich source of enzyme inducers, which help to detoxify carcinogens. The research findings were published in the 1997 Proceedings of the National Academy of Sciences USA.

Dr. Fahey has been an invited lecturer of various classes at the University of Maryland, Texas A&M University, University of Maryland School of Medicine and Johns Hopkins School of Public Health. He also has been an invited speaker at numerous international academic and business symposia including Seed Technology Workshops, International Horticultural Society Symposia, the International Symposium on Brassicas, the Moet-Hennessey Colloquium on Advanced Technology & Plant Breeding Strategy and the CNRS Antioxidant and Health Symposium.

Dr. Fahey is the author of numerous book chapters, technical publications and patents, including patented methods for deliberately inoculating grain seeds with beneficial bacteria, and for the production of dwarf rice plants.

Dr. Fahey graduated from Johns Hopkins University in 1975 and then earned a Master of Science degree in botany from the University of Maryland, and a doctorate in human nutrition from the Johns Hopkins University School of Public Health.

Dr. Fahey also teaches about phytochemicals via telelink at Texas A&M University and has been invited to lecture in such places as Germany, Shanghai, New Zealand and Japan.

Contact Information

Dr. Fahey receives mail at:

Department of Pharmacology
Johns Hopkins University School of Medicine
Wood Basic Science Building, Room 406
725 North Wolfe Street
Baltimore, Maryland 21205

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Patents

Some Related Papers

Dietary phytochemical delivery: Glucosinolates/isothiocyanates.

Fahey, J.W. (2002) Nutrition Today 37(5): 214-217.

Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea var. italica) sprouts and their effect on the induction of mammalian Phase 2 enzymes.

Pereira FM, Rosa E., Fahey JW, Stephenson KK, Carvalho R & Aires A. (2002)
J. Agric. Food Chem. 50: 6239-6244.

Urinary excretion of dithiocarbamates and self-reported Cruciferous vegetable intake: Application of the 'Method of Triads' to a food-specific biomarker.

Fowke, J.H., J.R. Hebert & J.W. Fahey. (2002)
Pub. Health Nutr. 5(6): 791-799.

"Brassicas" in Encyclopedia of Food Sciences and Nutrition

Fahey, J.W. (2003), Eds. B. Caballero, L.C. Trugo & P.M. Finglas, Academic Press, London. pp. 606-613.

Genetic and environmental effects on glucosinolate content and chemoprotective potency of broccoli.

Farnham MW, PE Wilson, KK Stephenson & JW Fahey. (2004) Plant Breeding 123: 60-65.

The "Prochaska" microtiter plate bioassay for inducers of NQO1.

Fahey JW, AT Dinkova-Kostova, P Talalay (2004) Chapter 14 in Methods in Enzymology, Vol. 382, Part B, pp. 243-258 (Eds.) H. Sies & L. Packer, Elsevier Science, San Diego, CA.

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

Proc. Natl. Acad. Sci. USA, Vol. 99, Issue 11, pp. 7610-7615, May 28, 2002

The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

Phytochemistry 2001, 56:5-51.

Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.

Food Chem Toxicol 1999 Sep-Oct;37(9-10):973-9

Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

Proc Natl Acad Sci USA 1997 Sep 16;94(19):10367-72

Chemoprotection against cancer by phase 2 enzyme induction.

Toxicol Lett 1995 Dec;82-83:173-9